SF Overdose Deaths Back on the Rise, After an Encouraging Decline in 2024

San Francisco faces a troubling resurgence in overdose deaths in 2025, following a hopeful decline in 2024. With 57 overdose deaths reported in May, the city is projected to reach 746 deaths this year, surpassing 2024's total of 635. Experts assert that the previous decline was misleading, as it stemmed from a supply shock that limited the availability of potent fentanyl. Now, drug suppliers are pivoting to synthetic opioids that may be more dangerous. This upward trend mirrors national statistics, with the CDC reporting an increase in overdose deaths across the United States.

In Seattle, overdose rates also approach all-time highs. The city's overdose crisis remains a significant political liability for Mayor Daniel Lurie, particularly following previous emergency declarations. As the situation evolves, public health officials emphasize the need for ongoing vigilance and effective responses.