High Doses of Adderall Linked to Increased Risk of Psychosis and Mania

Researchers from McLean Hospital have discovered a concerning link between high doses of prescription amphetamines, such as Adderall, and an increased risk of developing psychosis or mania. The study found that individuals taking 30 mg or more of dextroamphetamine, which is equivalent to 40 mg of Adderall, experienced a five-fold increase in the risk of these serious mental health issues. Conducted over nearly 15 years, the analysis reviewed emergency department admissions across Mass General Brigham hospitals, focusing on adults aged 16 to 35, a demographic typically affected by the onset of psychosis and schizophrenia. The researchers concluded that a staggering 81% of cases of new-onset psychosis or mania could have been avoided if patients had not been prescribed high doses of these stimulants. Lead author Lauren Moran highlighted the need for careful consideration of dosage when prescribing stimulant medications, particularly for patients with existing risk factors for psychosis.

While the study did not find a similar dose-related risk with methylphenidate (Ritalin), it underscores the importance of monitoring patients closely. Moran emphasized that there is limited evidence supporting the effectiveness of high doses of amphetamines, suggesting that alternative medications may be safer for at-risk patients. The findings advocate for a more cautious approach in clinical practices regarding stimulant prescriptions.